Blar i forfatter "Mellgren, Gunnar"

Viser treff 1-6 av 6

    • Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty 

      Madsen, Andre; Bruserud, Ingvild Særvold; Bertelsen, Bjørn-Erik; Roelants, Mathieu; Oehme, Ninnie; Viste, Kristin; Bjerknes, Robert; Almås, Bjørg; Rosendahl, Karen; Mellgren, Gunnar; Sagen, Jørn V.; Juliusson, Petur Benedikt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-22)
      <p><i>Context - </i>Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. <p><i>Objective - </i>To ...

    • Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

      Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-14)
      Abstract Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported thresholds for the two active metabolites, Z‐endoxifen and Z‐4‐hydroxy‐tamoxifen (Z‐4OHtam), ...

    • Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism 

      Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; Tasken, Kristin Austlid; Gauthier-Landry, Louis; Barbier, Olivier (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to address whether β2-adrenergic receptor (ADRB2)- mediated signaling may affect CRPC progression in vivo. By immunohistochemical analyses, we observed that low levels of ADRB2 is associated ...

    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-07)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to ...

    • Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications 

      Madsen, Andre; Almås, Bjørg; Bruserud, Ingvild Særvold; Oehme, Ninnie Helen Bakken; Nielsen, Christopher Sivert; Roelants, Mathieu; Hundhausen, Thomas Eckhard; Ljubicic, Marie Lindhardt; Bjerknes, Robert; Mellgren, Gunnar; Sagen, Jørn V.; Juliusson, Pétur Benedikt; Viste, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-17)
      Context: Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age.<p> <p>Objective: ...

    • Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC) 

      Horn, Cathrine; Gjerde, Eirin Semb; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen; Lawrence-Archer, Laurence; McCann, Adrian; Hansson, Patrik; Raza, Ghulam S.; Herzig, Karl Heinz; Lied, Gülen Arslan; Alho Letra Martins, Catia Patricia; Mellgren, Gunnar; Dierkes, Jutta; Dankel, Simon N (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-29)
      Background - Low-carbohydrate high-fat (LCHF) diets may suppress the increase in appetite otherwise seen after diet-induced fat loss. However, studies of diets without severe energy restriction are lacking, and the effects of carbohydrate quality relative to quantity have not been directly compared.<p> <p>Objectives - To evaluated short- (3 mo) and long-term (12 mo) changes in fasting plasma ...